Teaching chemical kinetics is often challenging because quantifying multistep reactions typically requires mathematically nontrivial analyses. Fitting enzyme kinetic data with kintek global kinetic. Making enzyme kinetics dynamic via simulation software journal. The instructor asks leading questions and guides the dialogue to create dynamic versions of three hallmark images sequentially figures 2. Project erp software that enables enterprise professional service firms to maximize the value of their people, work and time. An interactive classroom demonstration that enhances students knowledge of steadystate and michaelismenten enzyme kinetics is described. This video gives a brief introduction to the many unique features of kintek explorer. See the complete profile on linkedin and discover jims connections and jobs at similar companies. Johnson institute for cell and molecular biology, department of chemistry and biochemistry, university of texas at austin, 2500 speedway, mbb 3. Enzyme kinetics software kintek explorer kintek corporation. Data intelligence software the kic explorer software uses a modern, graphical interface that intuitively guides you through the task of profiling.
In addition, the software measures the process window index pwi statistic. The information it provides is extremely powerful and a real timesaver. Explorer software job cost accounting for construction. Our flagship product, eclipse, is a fully integrated browser based solution that offers over 30 modules, so users can track jobs, maintain equipment and manage their documents all in one place. Come to see the best, most precise and reliable instruments and dynamic simulation software for kinetic analysis booth 430. Weston tooling limited, precision tooling kintek madaula. Kintek corporation kintek and its suppliers grant to customer customer a nonexclusive and nontransferable license to use the kintek software software in object code form and run solely on a single central processing unit owned or leased by customer or its employees.
Originally designed for museums by museums, explorer understands the unique needs of nonprofits such as museums, zoos, and aquariums. This video introduces the different editors model editor, experiment editor, data fit editor, fitspace editor and data repository within the kintek explorer software kintek explorer student edition. For over 30 years, explorer software has been a leading provider of job cost accounting and project management software for the construction industry. Rigi prefers binding to dsrnaend and has a footprint of. This video gives a brief introduction to the many unique features of kintek explorer software in modeling kinetic and equilibrium data. The stoppedflow translocation kinetics were globally fit using the kintek explorer software to a minimal 5step model.
Aspentech software evaluation online product evaluations. Comprehensive admission, ticketing, gift shop, membership, fundraising software for science museums, childrens museums, art museums, zoos and aquariums. Weston tooling limited precision engineering tooling supplier of kintek madaula sauter vertex susta weston tooling limited is a family business founded in 1982 as weston engineering services now incorporated as weston tooling limited supplying the precision engineering industry with quality imported machine tool equipment. Introduces the different editors model editor, experiment editor, data fit editor, fitspace editor and data repository within the kintek explorer software. Kintek explorer is simulation and datafitting software for research and education designed specifically for the field of chemical kinetics. Shanzhong gong senior scientist i tango therapeutics. Timeresolved analysis of transcription through chromatin. The twostep nucleotide incorporation mechanism fig. Data fitting using the kintek explorer software, with permission. We then applied the fitspace analysis function in the kintek explorer software to explore the range wherein a pair of rate constants can covary and produce satisfying fits. The instructor uses a free version of professionalquality kintek explorer simulation software and student input to construct dynamic versions of three static hallmark images commonly used to introduce enzyme kinetic concepts.
View jim mcfarlanes profile on linkedin, the worlds largest professional community. The heart of the software is an optimized simulation engine, providing realtime visual feedback as the user scrolls model parameters such as reactionrate constants. Unless you have already purchased a license, the downloaded software will be. Download kintek explorer with over onehundred example projects which. See the complete profile on linkedin and discover shanzhong. Deltek delivers software and information solutions that enable superior levels of project intelligence, management and collaboration. Fitting enzyme kinetic data with kintek global kinetic explorer. Advanced chemical kinetics modeling, simulation, and data fitting software for windows and osx.
Behind the intuitive graphical user interface lies fast and efficient. Chapter 23 fitting enzyme kinetic data with kintek global kinetic. Teaching chemical kinetics with dynamic simulations. The progress curves of the singleturnover, singlenucleotide incorporation were obtained by simulation using kintek explorer software kintek inc.
Enzyme kinetics data fitting software kintek explorer. Enzyme kinetics software downloads kintek explorer. A new general method for simultaneous fitting of temperature and. Kintek global kinetic explorer software offers several advantages in fitting enzyme kinetic data. The instructor uses a free version of professionalquality kintek explorer simulation software and student input to construct dynamic versions of three static hallmark images commonly used to. Welcome to kintek engineering, inc kintek engineering inc. Intex explorer k2 kayak, 2person inflatable kayak set with aluminum oars and high output air pump.
Kintek respects and protects the privacy of our customers, prospective customers and others who use our website site and our products and services. Parameters used to constrain our model include chemical quench data as. This privacy statement provides details about how your personal information is collected and used by kintek. The quantified experimental data were fitted using the model 3 and the kintek explorer software. Come to see demonstrations of our groundbreaking autostoppedflow and kintek explorer kinetic simulation software.
The quality of fitting can be evaluated by the estimating the sigma standard deviation or p value 19 to 20 kenneth a. We are actively involved in reservoir modeling, wellbore planning, geosteering and project acquisition in north and south america. Rigi uses an atpasepowered translocationthrottling. Realtime dynamic simulation of progress curves as you drag rate constants and other parameters builds fast intuition about how your mechanism works, aids the planning and analysis of new experiments, and allows visual exploration of initial parameter values for. Now you can create and program your own television channel. Ppt kinetic modeling with kintek global explorer 3. We describe a new dynamic kinetic simulation program that. All your critical profile and process data are measured, including slope, peak temperature, time above liquidous, etc.
Newtek was founded in 1986 by inventor tim jenison. The kintek explorer is a powerful software package that changes the way you design and interpret experiments. Midcity excavating business analytics has really impressed us. Transient kinetics define a complete kinetic model for. It utilizes the free unlicensed version of kintek explorer10. Theres no software to install so you can get started immediately and its free.
The yielded confidence contour showed that the k d1 4863. Here, we describe the use of kintek explorer kinetic modeling software to fit kinetic data from a common twostep reaction i. Now you can easily evaluate key aspentech software products on your own, via the web. A new computer program for dynamic simulation and fitting of kinetic data. Deltek provides solutions designed to successfully align your two biggest assets your people and your projects throughout all areas of your business. Fluorescence stoppedflow methods were used to record the kinetics of enzyme conformational changes that monitor nucleotide binding and. Explorer is one of the finest nonprofit management software systems on the market today. By modifying kintek explorer software, we present a new general method for globally fitting data collected over a range of substrate concentrations and temperatures and apply it to hiv reverse transcriptase. Making enzyme kinetics dynamic via simulation software. Kintek software license agreement single user license grant.
Here, we describe the use of kintek explorer software. Our industryfocused expertise makes your projects successful and helps you achieve performance that maximizes productivity throughout the. Kintek global kinetic explorer software offers several advantages in fitting enzyme. Research work in biosflab relies on computer software, with strong preference towards the usage of free and open source software, starting from the operating system our laptops mostly run fedora and seldom other linux distributions. Several software packages are available for fitting kinetic data based on. This software allows you to organize and play videos, music videos, movies, commercials, advertisements, music and voice audio files, and send them to a video transmitter, live internet stream, tv channel modulator, video recorder, or other distribution device.
Representing a paradigm shift in data fitting, it takes you past all the simplifying assumptions normally used in fitting kinetic data to extract mechanistic information. View shanzhong gongs profile on linkedin, the worlds largest professional community. Realtime dynamic simulation of progress curves as you drag rate constants and other parameters builds fast intuition about how your mechanism works, aids the planning and analysis of new experiments, and allows visual exploration of initial parameter values for the best fits to your collected data. Fluorescence traces were analyzed using the kintek global explorer modeling software in order to obtain rate constants as described previously 58,59.
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